J H M Schellens Selected Research

trametinib

1/2022	Dabrafenib plus trametinib in patients with BRAF V600E-mutant anaplastic thyroid cancer: updated analysis from the phase II ROAR basket study.
4/2018	Development and validation of a liquid chromatography-tandem mass spectrometry analytical method for the therapeutic drug monitoring of eight novel anticancer drugs.
6/2016	Simultaneous quantification of dabrafenib and trametinib in human plasma using high-performance liquid chromatography-tandem mass spectrometry.

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J H M Schellens Research Topics

Disease

66	Neoplasms (Cancer) 01/2022 - 01/2002
14	Breast Neoplasms (Breast Cancer) 09/2019 - 07/2002
8	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 06/2002
6	Stomach Neoplasms (Stomach Cancer) 01/2021 - 02/2003
6	Prostatic Neoplasms (Prostate Cancer) 01/2017 - 09/2002
5	Neutropenia 07/2015 - 11/2005
4	Disease Progression 01/2022 - 07/2015
4	Sarcoma (Soft Tissue Sarcoma) 07/2020 - 08/2003
4	Melanoma (Melanoma, Malignant) 01/2017 - 06/2013
4	Colorectal Neoplasms (Colorectal Cancer) 04/2015 - 01/2002
3	Carcinoma (Carcinomatosis) 01/2021 - 06/2002
3	Lymphoma (Lymphomas) 07/2018 - 02/2007
3	Hand-Foot Syndrome 06/2016 - 04/2015
3	Fatigue 06/2016 - 11/2005
2	Renal Cell Carcinoma (Grawitz Tumor) 07/2020 - 12/2017
2	Leishmaniasis 02/2017 - 04/2016
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2017 - 08/2016
2	Cardiotoxicity 06/2016 - 07/2011
2	Neoplasm Metastasis (Metastasis) 03/2016 - 03/2004
2	Nausea 06/2015 - 06/2007
2	Vomiting 06/2015 - 06/2007
2	Hyperbilirubinemia 01/2014 - 07/2006
2	Colonic Neoplasms (Colon Cancer) 09/2013 - 09/2010
2	Necrosis 12/2008 - 08/2004
1	Anaplastic Thyroid Carcinoma 01/2022
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2022
1	Peritonitis 01/2021
1	Peritoneal Diseases 10/2020
1	Squamous Cell Carcinoma of Head and Neck 09/2019

Drug/Important Bio-Agent (IBA)

22	Pharmaceutical PreparationsIBA 04/2018 - 07/2002
9	Paclitaxel (Taxol)FDA LinkGeneric 10/2014 - 12/2002
8	Cisplatin (Platino)FDA LinkGeneric 04/2015 - 12/2002
7	PlatinumIBA 01/2022 - 06/2002
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2002
6	Capecitabine (Xeloda)FDA Link 12/2017 - 01/2014
6	Gemcitabine FDA Link 12/2015 - 11/2005
4	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2021 - 08/2005
4	Docetaxel (Taxotere)FDA Link 01/2021 - 07/2003
4	Tamoxifen FDA LinkGeneric 11/2018 - 08/2009
4	niraparibIBA 01/2018 - 01/2017
4	eribulin FDA Link 07/2015 - 12/2012
4	Antineoplastic Agents (Antineoplastics)IBA 07/2015 - 01/2002
4	Cyclosporine (Ciclosporin)FDA LinkGeneric 10/2007 - 12/2002
3	dabrafenibIBA 01/2022 - 06/2016
3	trametinibIBA 01/2022 - 06/2016
3	Everolimus FDA Link 01/2019 - 06/2015
3	Fluorouracil (Carac)FDA LinkGeneric 12/2017 - 10/2014
3	miltefosine (Impavido)IBA 02/2017 - 08/2015
3	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2014 - 05/2005
3	TrabectedinIBA 04/2010 - 08/2003
3	Capsules (Microcapsules)IBA 04/2010 - 01/2002
3	Methotrexate (Mexate)FDA LinkGeneric 02/2010 - 07/2006
3	tipifarnib (R115777)IBA 11/2005 - 01/2002
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2021 - 11/2012
2	pazopanib FDA Link 07/2020 - 12/2017
2	olaparibIBA 09/2019 - 12/2013
2	enzalutamideIBA 04/2018 - 01/2017
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2018 - 01/2017
2	plitidepsin (aplidine)IBA 01/2018 - 10/2017
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 12/2017 - 01/2017
2	VemurafenibIBA 01/2017 - 01/2014
2	vosaroxinIBA 01/2017 - 08/2016
2	QuinolonesIBA 01/2017 - 08/2016
2	Cytarabine (Cytosar-U)FDA LinkGeneric 08/2016 - 02/2010
2	IntegrinsIBA 01/2016 - 06/2011
2	N- (3- cyano- 4- methyl- 1H- indol- 7- yl)- 3- cyanobenzene- sulfonamideIBA 01/2016 - 06/2011
2	Tyrosine Kinase InhibitorsIBA 10/2015 - 11/2011
2	Topotecan (Hycamtin)FDA LinkGeneric 09/2015 - 07/2002
2	Prostate-Specific Antigen (Semenogelase)IBA 07/2015 - 07/2015
2	Epirubicin (Ellence)FDA LinkGeneric 04/2015 - 10/2014
2	taxaneIBA 04/2014 - 04/2013
2	CP 4126IBA 08/2013 - 08/2013
2	Messenger RNA (mRNA)IBA 11/2011 - 06/2011
2	Biomarkers (Surrogate Marker)IBA 06/2011 - 01/2006
2	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 09/2010 - 07/2002
2	indibulinIBA 04/2010 - 06/2007
2	TransferasesIBA 06/2008 - 06/2002
2	BilirubinIBA 11/2007 - 07/2006
2	SolutionsIBA 10/2007 - 06/2007
2	Blood Proteins (Serum Proteins)IBA 02/2007 - 01/2006
2	Phenytoin (Dilantin)FDA LinkGeneric 01/2007 - 08/2006
2	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2005 - 09/2004
2	Irinotecan (Camptosar)FDA LinkGeneric 10/2004 - 09/2004
2	SulfonamidesIBA 10/2002 - 08/2002
2	N- (3- chloro- 7- indolyl)- 1,4- benzenedisulphonamide (E7070)IBA 10/2002 - 08/2002
1	PM 01183IBA 01/2022
1	Gefitinib (Iressa)FDA Link 01/2021
1	Circulating Tumor DNAIBA 01/2021
1	Immune Checkpoint InhibitorsIBA 01/2019
1	TOR Serine-Threonine KinasesIBA 01/2019

Therapy/Procedure

16	Drug Therapy (Chemotherapy) 01/2022 - 01/2002
13	Therapeutics 01/2022 - 03/2002
4	Castration 01/2017 - 06/2015
3	Radiotherapy 09/2019 - 01/2002
3	Oral Administration 10/2007 - 06/2002
2	Hyperthermic Intraperitoneal Chemotherapy 01/2021 - 10/2020
2	Cytoreduction Surgical Procedures 01/2021 - 10/2020
2	Chemoradiotherapy 10/2014 - 05/2008
1	Gastrectomy 01/2021
1	Immunotherapy 01/2019